| Assay ID | Title | Year | Journal | Article |
|---|
| AID342130 | Selectivity for human p38alpha over JNK3 | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389570 | Binding affinity to human LKB1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390072 | Binding affinity to human TYK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390057 | Binding affinity to human EPHA5 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID599583 | Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISA | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. |
| AID389533 | Binding affinity to human MSK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390080 | Binding affinity to human RIPK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389596 | Binding affinity to human CLK4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389536 | Binding affinity to human RSK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389633 | Binding affinity to human GCN2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342148 | Inhibition of LPS-stimulated TNF alpha release in human whole blood cells by ELISA | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID390010 | Binding affinity to human LCK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389601 | Binding affinity to human CK2A2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349059 | Inhibition of EGFR | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID349063 | Inhibition of PLK1 | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID390064 | Binding affinity to human EPHB4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390032 | Binding affinity to human PDGFRB at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390063 | Binding affinity to human EPHB3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349051 | Inhibition of LPS-stimulated TNFalpha release in human whole blood | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID341053 | Ratio of IC50 for HSP27 phosphorylation to IC50 for p38alpha phosphorylation in IL-1-alpha-stimulated HLF cells | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID389555 | Binding affinity to human PHKG1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390045 | Binding affinity to human AXL at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390003 | Binding affinity to human ARG at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390026 | Binding affinity to human KDR at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390058 | Binding affinity to human EPHA4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389604 | Binding affinity to human KHS1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390053 | Binding affinity to human ERBB4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390075 | Binding affinity to human TESK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390018 | Binding affinity to human CSK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389628 | Binding affinity to human TLK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390027 | Binding affinity to human FLT1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390071 | Binding affinity to human JAK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID599582 | Inhibition of p38alpha-dependent TNFalpha production in human PBMC preincubated for 1 hr before LPS challenge by ELISA | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. |
| AID389535 | Binding affinity to human RSK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389561 | Binding affinity to human BRSK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389598 | Binding affinity to human CLK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390002 | Binding affinity to human ABL at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342125 | Selectivity for human p38alpha over AKT1 | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID390024 | Binding affinity to human FGFR4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389615 | Binding affinity to human LOK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390038 | Binding affinity to human INSR at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390009 | Binding affinity to human LYN at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389571 | Binding affinity to human AURC at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390050 | Binding affinity to human TNK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389618 | Binding affinity to human PAK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389550 | Binding affinity to human CAMK1G at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389603 | Binding affinity to human MAP3K4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389585 | Binding affinity to human ERK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390007 | Binding affinity to human ITK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389589 | Binding affinity to human JNK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389620 | Binding affinity to human PAK5 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389608 | Binding affinity to human TNIK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390012 | Binding affinity to human SRC at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342134 | Inhibition of human recombinant CYP1A2 transfected in Escherichia coli co-expressed with human NADPH reductase | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID342141 | Volume of distribution at steady state in Lewis rat at 0.5 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID342143 | Oral bioavailability in Lewis rat at 1.5 mg/kg | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID342123 | Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human GST-tagged p38alpha by fluorescence polarisation assay | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID342128 | Selectivity for human p38alpha over EphB4 | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID342138 | Inhibition of human recombinant CYP2C9 transfected in Escherichia coli co-expressed with human NADPH reductase | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID390023 | Binding affinity to human FGFR1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342144 | Ratio of drug level in brain to plasma in Lewis rat at 0.5 mg/kg, iv and 1.5 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389582 | Binding affinity to human CDK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389572 | Binding affinity to human AURB at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389600 | Binding affinity to human CK2A1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390079 | Binding affinity to human RAF1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342133 | Selectivity for human p38alpha over Syk | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389558 | Binding affinity to human STK33 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390033 | Binding affinity to human FLT3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342124 | Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human GST-tagged p38beta by fluorescence polarisation assay | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID390081 | Binding affinity to human CK1a2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390087 | Binding affinity to human TTK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390078 | Binding affinity to human BRAF at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390001 | Binding affinity to human ACTR2B at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389098 | Binding affinity to human AKT1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389607 | Binding affinity to human HGK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390066 | Binding affinity to human EPHA2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342147 | Antiinflammatory activity against collagen-induced arthritis in DBA/1 mouse model at 30 mg/kg/day, po for 14 days | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID390034 | Binding affinity to human TIE2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389636 | Binding affinity to human ALK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390074 | Binding affinity to human LIMK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389586 | Binding affinity to human ERK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389621 | Binding affinity to human PAK6 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342139 | Inhibition of LPS-stimulated TNF alpha release in human PBMC cells by ELISA | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID342136 | Inhibition of human recombinant CYP2D6 transfected in Escherichia coli co-expressed with human NADPH reductase | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID390068 | Binding affinity to human FAK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389630 | Binding affinity to human AAK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389578 | Binding affinity to human DAPK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID1540358 | Inhibition of P38alpha MAPK (unknown origin) | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation. |
| AID389560 | Binding affinity to human AMPKA2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390036 | Binding affinity to human LTK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389546 | Binding affinity to human YANK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390011 | Binding affinity to human BLK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389565 | Binding affinity to human QIK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389556 | Binding affinity to human PHKG2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389998 | Binding affinity to human TGFBR1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389568 | Binding affinity to human CAMKK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389595 | Binding affinity to human CLK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389590 | Binding affinity to human JNK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390014 | Binding affinity to human FYN at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389610 | Binding affinity to human MST2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342140 | Clearance in Lewis rat plasma at 0.5 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389614 | Binding affinity to human SLK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389564 | Binding affinity to human MARK4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389597 | Binding affinity to human CLK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390077 | Binding affinity to human MLK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390055 | Binding affinity to human ZAP70 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389635 | Binding affinity to human ALK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389569 | Binding affinity to human CAMKK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349061 | Inhibition of JNK3 | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID389554 | Binding affinity to human CAMK2G at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389567 | Binding affinity to human PIM2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390061 | Binding affinity to human EPHB1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390021 | Binding affinity to human FGFR2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389623 | Binding affinity to human FUSED at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349058 | Inhibition of cFMS | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID389606 | Binding affinity to human HPK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389617 | Binding affinity to human PAK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390086 | Binding affinity to human MPSK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390062 | Binding affinity to human EPHB2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390030 | Binding affinity to human KIT at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342126 | Selectivity for human p38alpha over Aurora A | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID341193 | Binding affinity to human unphosphorylated p38alpha by surface plasmon resonance | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID390031 | Binding affinity to human PDGFRA at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389627 | Binding affinity to human NEK7 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389602 | Binding affinity to human MAP3K5 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389634 | Binding affinity to human MYT1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390019 | Binding affinity to human FER at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390015 | Binding affinity to human FGR at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389553 | Binding affinity to human CAMK2B at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389581 | Binding affinity to human SKMLCK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389563 | Binding affinity to human MARK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389538 | Binding affinity to human PRKX at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349056 | Inhibition of MEK1 by cRaf/mek/Erk cascade assay | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID389573 | Binding affinity to human AURA at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389099 | Binding affinity to human AKT2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390029 | Binding affinity to human FMS at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389574 | Binding affinity to human PLK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID599584 | Inhibition of human CYP2C9 expressed in Escherichia coli by fluorimetric assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. |
| AID389280 | Binding affinity to human PKCA at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390025 | Binding affinity to human RET at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342146 | Antiinflammatory activity against collagen-induced arthritis in DBA/1 mouse model at 15 mg/kg/day, po for 14 days | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389547 | Binding affinity to human YANK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID341192 | Ratio of IC50 for LPS-stimulated TNFalpha release in human PBMC to Ki for human p38alpha | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID390006 | Binding affinity to human TXK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID341050 | Inhibition of human recombinant p38alpha-mediated ATF2 phosphorylation by TR-FRET assay | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID390005 | Binding affinity to human BMX at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390049 | Binding affinity to human ACK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389629 | Binding affinity to human TLK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390052 | Binding affinity to human ERBB2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID341052 | Inhibition of p38alpha phosphorylation in IL-1-alpha-stimulated HLF cells | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID389575 | Binding affinity to human PLK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342132 | Selectivity for human p38alpha over ROCK1 | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID342149 | Inhibition of human recombinant His-tagged p38alpha-mediated ATF2 phosphorylation by TR-FRET assay | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID390082 | Binding affinity to human CK1d at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389100 | Binding affinity to human AKT3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389545 | Binding affinity to human PDK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390069 | Binding affinity to human PYK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389559 | Binding affinity to human AMPKA1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389999 | Binding affinity to human BMPR1A at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389551 | Binding affinity to human CAMK2A at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389541 | Binding affinity to human PKG2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389584 | Binding affinity to human PCTAIRE1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389594 | Binding affinity to human GSK3A at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389583 | Binding affinity to human CDK5 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390004 | Binding affinity to human BTK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390088 | Binding affinity to human ADCK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389532 | Binding affinity to human PKN2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390085 | Binding affinity to human CK1g2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389531 | Binding affinity to human PKCH at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342131 | Selectivity for human p38alpha over Lck | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID342145 | Antiinflammatory activity against peptidoglycan polysaccharide-induced arthritis in rat reactivation model after 14 days | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID599580 | Inhibition of GST-tagged p38alpha by fluorescence polarization method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. |
| AID349062 | Inhibition of LCK | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID390040 | Binding affinity to human IRR at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID341049 | Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human p38alpha by fluorescence polarization | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID389534 | Binding affinity to human MSK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390046 | Binding affinity to human MER at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390017 | Binding affinity to human BRK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389562 | Binding affinity to human MARK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389588 | Binding affinity to human JNK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390054 | Binding affinity to human SYK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390056 | Binding affinity to human EPHA3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342135 | Inhibition of human recombinant CYP2C19 transfected in Escherichia coli co-expressed with human NADPH reductase | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID390008 | Binding affinity to human HCK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349057 | Inhibition of CDK2 | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID390020 | Binding affinity to human FES at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390028 | Binding affinity to human FLT4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390076 | Binding affinity to human HH498 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390043 | Binding affinity to human TRKA at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389544 | Binding affinity to human NDR2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390044 | Binding affinity to human MUSK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390083 | Binding affinity to human CK1e at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389557 | Binding affinity to human MNK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389609 | Binding affinity to human MST1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389632 | Binding affinity to human GAK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389619 | Binding affinity to human PAK4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389593 | Binding affinity to human P38G at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390067 | Binding affinity to human EPHA1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390000 | Binding affinity to human ACTR2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390022 | Binding affinity to human FGFR3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390041 | Binding affinity to human TRKB at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390065 | Binding affinity to human EPHA8 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390013 | Binding affinity to human YES at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342142 | Terminal half life in Lewis rat plasma at 0.5 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389613 | Binding affinity to human MST4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389543 | Binding affinity to human DMPK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390089 | Binding affinity to human ADCK4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389616 | Binding affinity to human PAK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390035 | Binding affinity to human ALK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349065 | Inhibition of VEGFR2 | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID342127 | Selectivity for human p38alpha over EGFR | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389580 | Binding affinity to human DRAK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389599 | Binding affinity to human SRPK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390073 | Binding affinity to human LIMK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390042 | Binding affinity to human TRKC at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389539 | Binding affinity to human PKACB at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390037 | Binding affinity to human ROS at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389591 | Binding affinity to human P38A at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389579 | Binding affinity to human DRAK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389576 | Binding affinity to human PLK4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389611 | Binding affinity to human MST3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342137 | Inhibition of human recombinant CYP3A4 transfected in Escherichia coli co-expressed with human NADPH reductase | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389612 | Binding affinity to human YSK1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389540 | Binding affinity to human PKG1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389637 | Binding affinity to human ALK4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389542 | Binding affinity to human MRCKA at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390070 | Binding affinity to human JAK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390084 | Binding affinity to human CK1gamma1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389577 | Binding affinity to human DAPK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390059 | Binding affinity to human EPHA6 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID341051 | Inhibition of HSP27 phosphorylation in IL-1-alpha-stimulated HLF cells | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID349064 | Inhibition of SGK1 | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID389548 | Binding affinity to human CAMK1A at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390047 | Binding affinity to human TYRO3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389537 | Binding affinity to human RSK4 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389549 | Binding affinity to human CAMK1D at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID341194 | Inhibition of p38beta | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID389626 | Binding affinity to human NEK6 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389605 | Binding affinity to human KHS2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID341054 | Inhibition of LPS-stimulated TNFalpha release in human PBMC by ELISA | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. |
| AID389624 | Binding affinity to human NEK2 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349066 | Inhibition of LPS-stimulated TNFalpha release in human PBMCs | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID389592 | Binding affinity to human P38B at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389587 | Binding affinity to human NLK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389566 | Binding affinity to human PIM1 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390039 | Binding affinity to human IGF1R at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID342129 | Selectivity for human p38alpha over GSK3-beta | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. |
| AID389552 | Binding affinity to human CAMK2D at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390016 | Binding affinity to human FRK at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389631 | Binding affinity to human BIKE at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390048 | Binding affinity to human MET at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID349060 | Inhibition of ErbB4 | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Kinase array design, back to front: biaryl amides. |
| AID390060 | Binding affinity to human EPHA7 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID390051 | Binding affinity to human EGFR at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389625 | Binding affinity to human NEK9 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| AID389622 | Binding affinity to human ULK3 at 10 uM relative to control | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
| Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |